Left: Young mice, before puberty (2 weeks old), have many nestin-positive (green) mesenchymal stem cells (MSCs) in the primary spongiosa to maintain or build bone mass during bone elongation initiated by the growth plate above. Right: Mice treated with the glucocorticoid prednisolone are missing that population of cells, contributing to the development of osteoporosis. The nuclei of cells are shown in blue. / Courtesy of Mei Wan, Ph.D.

“All 192 patients underwent a total hip replacement through the high-risk algorithm, with dual mobility implants being used in 143 of the cases.”

“We found that patients with a spinal fusion of greater than three levels were patients that were the highest risk. There are also cumulative risks, such as a spinal fusion of one or two levels combined with a stiff spine. These high-risk patients need specific targets for their hip replacement, found out through a far more detailed preop workup than previously performed. Some of them also need use of computer navigation or even a dual mobility prosthesis to help mitigate the risk.”

“The biggest recommendation is really a thorough preop workup including a standing and sitting X-ray of the pelvis and also the lumbar spine. This will help to determine through the algorithm which patients are at risk.”

The study has been submitted for publication.

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