Predicting Death Risk After Hip Fracture

A new multicenter study is opening the door to predicting mortality risk after hip fracture. In what is the first documented application of a tissue-specific DNA methylation age within an orthopedic trauma cohort, the study team published their work, “Blood and Bone-Derived DNA Methylation Ages Predict Mortality After Geriatric Hip Fracture. A Pilot Study,” in the February 19, 2025, edition of The Journal of Bone and Joint Surgery.   

Co-author Sandip Tarpada, M.D., with the Department of Orthopaedic Surgery at the R Adams Cowley Shock Trauma Center, University of Maryland Medical Center in Baltimore, described the origins of this work to OTW, “This research was driven by the persistent challenge of high mortality rates in geriatric hip fracture patients.”